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Early Detection of Tuberculosis Using Culture Filtrate Proteins of Mycobacterium Tuberculosis in Serological Assays
Inventors: Dr. Suman Laal, Dr. Susan Zolla-Pazner, Dr. John Belisle
Summary of the Technology:
A number of protein and glycoprotein antigens secreted by Mycobacterium.
tuberculosis (Mt) have been identified as "early" Mt antigens
on the basis early antibodies present in subjects infected with Mt prior
to the development of detectable clinical disease. These early Mt antigens,
in particular an 88 kDa secreted protein having a pI of about 5.2 present
in Mt lipoarabinomannan-free culture filtrate, a protein characterized
as Mt antigen 85C; a protein characterized as Mt antigen MPT51, a glycoprotein
characterized as Mt antigen MPT32; and a 49 kDa protein having a pI
of about 5. 1, are useful in immunoassay methods for early, rapid detection
of TB in a subject. Also provided are antigenic compositions, kits and
methods useful for detecting an early Mt antigen, an early Mt antibody,
and immune complexes thereof. For the first time, a surrogate marker
is available for inexpensive screening of individuals at heightened
risk for developing TB, in particular HIV-1 infected subjects and other
immunocompromised individuals.
Patent:
US 6,245,331 “Early Detection of Mycobacterial
Diasease,”
US 6,506,384 “Early Detection of Mycobacterial Disease,”
AUS 746,752 “Mycobacterial Diasease”
Licensing Contact:
Dian Marie Kammeyer
Senior Licensing Associate
Colorado State University Research Foundation
P.O. Box 483
Fort Collins, CO 80522
dian.kammeyer@csurf.colorstate.edu
970/482-2916 Phone
970/484-0354 Fax
This page was last updated September 24, 2007.