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| Inexpensive, Reusable Electrochemical Biosensor with Low Detection Limit and High Signal-to-Noise |
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DNA detection method utilizing an electrochemical signal amplification technique. Reliably detects low-levels of sequence-specific DNA.
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| Non-Medical Grade Silicone Vessels for Simulation Models and Multilayer Artificial Abdominal Walls |
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This is a multilayer artificial abdominal body wall that has similar tissue texture and consistency when compared to the ones found in live animals or humans. This MAABW has silicon-based blood vessels that are integrated within its multilayer structure. These vessels are interconnected and can support moderate intra-luminal liquid pressure, similar to the diastolic blood pressure encountered in many different species. Their purpose is to “bleed” once they are cut, and therefore will give the trainee the opportunity to learn and or practice basic methods of surgical hemostasis.
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| The Rv3129/Rv3130 Operon as a Target for Tuberculosis Vaccines and Diagnostics |
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A series of recombinant proteins have been constructed with strong ELISA reactions to sera from children with latent TB infections. Potential future as a vaccine.
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| Vaccine for Tuberculosis Obtained from Infected Lung Tissues |
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Vaccine targets for tuberculosis from infected lung tissues.
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| BluePort: A New Vaccination Platform |
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Immune portal for vaccine administration. Removes the need for traditional adjuvants by providing a site for vaccine administration with enhanced immune stimulation.
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| The Use of In-vitro Attached Microbial Communities to Screen for New Drugs |
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Method to rapidly and more accurately generate bacterial biofilms for drug screening.
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| Adamantyl and Adamantyl like Substituted Ureas as New Drugs for Tuberculosis |
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A series of TB drugs based on substituted ureas. Several lead compounds are being developed.
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| ISPD Inhibitor, ISPE Inhibitor and Sulfonamide Derivatives |
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Several new compounds were synthesized and purified that act on a bacterial synthesis pathway not present in mammals.
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| Triazino-indoles and related compounds as inhibitor enzyme dTDP-6-deoxy-xylo-4-hexulose 3,5-epimerase (RmlC) and as drugs against tuberculosis |
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Lead compounds that inhibit an enzyme essential to the formation of linker molecules essential to bacterial cell wall structural integrity have been elucidated. Testing has demonstrated robust inhibition of the enzyme in vitro.
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| Napkthol Alkyl Derivatives as MenA Inhibitor |
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New compounds have been created that inhibit the Menaquinone A (MenA) metabolic pathway. Primary experiments have shown success in TB, but the MenA pathway is ubiquitous in gram positive bacteria.
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| 2nd Generation Tuberculin Skin Test (TST) Antigens |
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Heat shock proteins that enhance antigen presentation and stimulate innate immune resonses can be used in an assay utilizing newly isolated purified mycobacterial proteins.
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| A New Post-exposure Vaccine for Tuberculosis |
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A series of proteins have been elucidated that reduce bacterial load and lung pathology, in guinea pigs, when administered 30-60 days after exposure to TB.
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| Biomarkers for Tuberculosis |
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Several biomarkers have been identified from urine and sputum of TB infected individuals. These markers change in relative abundance throughout the course of treatment. These markers could be used to assess treatment efficacy.
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| Guinea Pig Biomarker for M. Tuberculosis Drug and Vaccine Efficacy |
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The guinea pig is the preferred animal model for TB research. Several biomarkers have been identified that can predict the reactivation of a latent infection. These markers could be used to prevent reactivation and reduce drug resistance.
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| A Personal, Active Sampling Device for Estimating Total Aerosol Deposition in the Human Respiratory Tract |
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Device and algorithm to detect the amount of aerosol absorbed into a lung. More accurately predicts exposure over sampling of air in the exposure space.
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| Electro-spraying Process for Applying Coatings on Metal Implants |
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A syringe containing the source material (phospholipid) to be "sprayed" is mounted on a syringe pump. The needle of the source syringe and the target material are each connected to a voltage source. As the pum is activated, source material leaves the syringe and "sprays" in a very fine mist onto the target material. The resulting surfaces are thin, adherent and consistent. This process creates rougher, porous surfaces that are better for cell growth, or thicker for slow release of drugs.
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| A Short-step Synthesis of Capuramycin, MDR-TB Drug |
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Researchers at CSU have significatnly improved the synthesis of Capuramycin.
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| Tissue Archival Database |
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A database to enable tracking of tissue samples. Database information includes patient information, diagnosis, histology, freeze/thaw cycles and sample location. Labels are generated from the database for sample tubes.
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| Synthesis and Biological Activity of the Peptide Isotere of the HDAC Inhibitor FK228 |
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A peptide isotere of the HDAC inhbitor FK228 and a low-cost method of synthesis of the compound sutiable to industrial size manufacturing processes.
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| Rapid Test to Measure Metabolic Activity in Culture |
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Method to Observe the Growth of TB Bacteria Culture on a Significantly Shorter Time Scale.
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| External Device to Correct Functional Mitral Regurgitation |
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An external device that would reduce functional mitral regurgitation in patients with dilated cardiomyopathy. This device could be applied around the heart without requiring cardiopulmonary bypass and without being in contact with blood.
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| Dynamic Stabilization Device for the Correction of the Instantaneous Axis of Rotation in the Lumbar Spine |
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The device is a bilateral pedicle screw-based system connected by titanium rods that incorporates movement in the screw-body interface to project the center of rotation out of the implant.
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| Scalable HIV-1 Protease Assay |
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Assay for drugs interfering with HIV protease maturation. Utilizes the native protease protein, not a synthetically generated molecule with incorrect folding. Assay available in E. coli and mammalian cell lines.
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| Population-Based Phamacokinetic in silico Analysis to Estimate Drug Variability and Response in Human and Animal Populations |
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Physiologically-based pharmacokinetic (PBPK) modeling methodologies are the most scientifically sound and rigorous approaches for simulating absorption, distribution, metabolism, and elimination of xenobiotics. The utility for this technology is predicting whether a drug should be dosed based on body weight, surface area, a fixed dose, or whether caution should be taken with specific populations with known issues or deficiencies in an identical critical route of elimination or other pathologies. This would optimize dosing schema for a given agent within and between populations. In addition, this method would predict variability and traits in a given population that make individuals more susceptible to adverse drug events or therapeutic failure.
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| Chemically Modified Nanoparticles for Targeted Imaging and Treatment of Various Diseases and Methods for Making and Using Such Nanoparticles |
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A canine diagnostic test to quantify the amount of an important lymphocyte subset called regulatory T-cells (Treg).
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| Mucosal Pocket at the Interface Between an Osseointegrative Implant for Anchorage of an External Prosthesis and Skin |
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Following amputation, either surgical or traumatic, an osseointegrative implant is placed in the long bone of a damaged limb. A granulation bed will be made and encouraged to form a cup. A graft from the mucosal epithelium will be used to connect the skin to the mucosa creating a mucosal lined socket that covers the end of the amputated bone. The mucosal cup/implant stays moist, which is less irritating, has inherent antibacterial properties, requires less hygenic care, and eliminates hair growth into the implant/soft tissue interface. All these factors reduce the incidence of infection and maintain a permanent successful implant/body interface.
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| Tissue Decellularization and Antigen Removal by Tissue-Gel Electrophoresis |
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A novel method for the decelluarization of allograft and xenograft tissues using tissue-gel electrophoresis.
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| Anticancer and Antidiabetic Compound Interaction with Lipid Interfaces |
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Microemulsions of AOT can be used a a drug carrier. This method of drug delivery is simple, non-toxic, and more controllable than current methodologies.
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| Targeted Delivery of Bisphosphonates and an Anti-neoplastic Agent to Metastic Bone Lesions |
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Microemulsion formulations incorporating bisphosphonate and an anti-neoplastic agent as a delivery vehical for multimodal targeted therapy of metastic bone cancer.
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| Repetitive Sequence-Free DNA Libraries |
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A simple method for producing significant volumes of chromosome-specific painting probes.
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| Menaquinone Synthesis Inhibitors against MDR-TB and other Pathogenic Bacteria |
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A Pseudomonas aeruginosa strain deficient in five efflux pumps (providing susceptibility) and the sole type three secreation system (providing biosafety). Useful for the deterimination of efflux susceptibility of drugs and characterization of efflux pumps from other bacteria.
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| A Biomarker Assay Utilizing Telomere Dysfunction to Evaluate Risk of Developing Breast Cancer |
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A diagnostic assay to identify telomere dysfunction, which can serve as a sensitive biomarker for genomic instability.
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| Vacuum Based Adsorption of Contaminants: VacBAC |
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A field portable device to sample large volumes of water and concentrate microorganisms rapidly, easily, and in a manner that enables reliable detection.
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Aerosol Sampling Device for Estimating Total Aerosol Deposition in the Human Respiratory Tract |
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Device and algorithm to detect the amount of aerosol absorbed into a lung. More accurately predicts exposure over sampling of air in the exposure space.
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Rugged, Omnidirectional Dosimeter for Improved, Real-time Measurement of Human Exposure to Harmful Radiation |
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A small, economical dosimeter for measuring harmful radiation. Unlike other devices, this dosimeter displays no directional dependence of the incoming radiation.
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| Low Cost Neonatal Transport Incubator for First Responders or Newly Industrialized Countries |
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A low cost backpack for neonatal transport. The device is light-weight, adaptable, and exceeds safety criteria for the transport of newborns.
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